Hyperbaric Sub-Normothermic Ex-Vivo Perfusion Delays the Onset of Acute Rejection in a Porcine VCA Model.
نویسندگان
چکیده
INTRODUCTION: Vascularized composite allotransplantation (VCA) offers superior functional recovery following devastating maxillofacial and upper limb injuries compared to traditional reconstructive techniques. Here, we evaluate the efficacy of a novel sub-normothermic (SN) ex-vivo perfusion strategy using hyper-oxygenated University of Wisconsin (UW) solution to mitigate reperfusion injury (RI) and the onset of acute rejection in a porcine VCA model. 1 Minimizing RI by optimizing allograft preservation strategies could improve early VCA outcomes, and reduce dose, frequency, and duration of immunosuppression.
منابع مشابه
Normothermic ex vivo allograft blood perfusion in clinical heart transplantation.
BACKGROUND Cold ischemia associated with cold static storage is an independent risk factor for primary allograft failure and survival of patients after orthotopic heart transplantation. The effects of normothermic ex vivo allograft blood perfusion on outcomes after orthotopic heart transplantation compared to cold static storage have been studied. METHODS In this prospective, nonrandomized, s...
متن کاملNormothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Kidney transplantation has become a well-established treatment option for patients with end-stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the acceptance criteria for organ donors have been extended leading to the usage of marginal kidney grafts. These marginal organs tolerate cold storage poorly resulting in increased preservation injury and higher rat...
متن کاملNormothermic kidney preservation.
PURPOSE OF REVIEW Kidneys from marginal or donation after cardiac death (DCD) donors are particularly susceptible to injury during hypothermic preservation and may benefit from alternative methods of preservation. Normothermic preservation can be adapted to improve the quality of kidneys for transplantation by a variety of techniques. RECENT FINDINGS Extracorporeal membrane support to maintai...
متن کاملA paired study comparing the efficacy of renal preservation by normothermic autologous blood perfusion and hypothermic pulsatile perfusion.
THE REDUCTION in metabolic rate effected by hypothermia constitutes the central tenet of traditional organ preservation. The antithesis of this approach is to provide for metabolic demand during normothermic preservation. This latter strategy has two potential benefits. First, if metabolic requirements are met during preservation, then longer preservation with better posttransplant function may...
متن کاملAcute Administration of Natural Honey Protects Isolated Heart in Normothermic Ischemia
This study intended to assess the efficacy of acute administration of natural honey on cardiac arrhythmias and infarct size when it is used during the normothermic ischemia in isolated rat heart. During 30 min of regional normothermic ischemia followed by 120 min of reperfusion, the isolated hearts were perfused by a modified drug free Krebs-Henseleit solution (control) or the solution containi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Plastic and reconstructive surgery
دوره 136 4 Suppl شماره
صفحات -
تاریخ انتشار 2015